HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure
Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes.ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity.ALF has a high mortality that is associated with multiple organ failure (MOF) and sepsis; however, the underlying mechanisms are still not clear.Emerging evidence