HMGB1 AND EXTRACELLULAR HISTONES SIGNIFICANTLY CONTRIBUTE TO SYSTEMIC INFLAMMATION AND MULTIPLE ORGAN FAILURE IN ACUTE LIVER FAILURE

HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure

Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes.ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity.ALF has a high mortality that is associated with multiple organ failure (MOF) and sepsis; however, the underlying mechanisms are still not clear.Emerging evidence

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Physiological reactivity at rest and in response to social or emotional stimuli after a traumatic brain injury: A systematic review

Numerous studies have shown that alterations in physiological reactivity (PR) after traumatic brain injury (TBI) are possibly associated with emotional deficits.We conducted a systematic review of these studies that evaluated PR in adults with moderate-to-severe TBI, either at rest or in response to emotional, stressful, or social stimuli.We focuse

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